Table 3 Effects of inactivation of orthologous genes corresponding to major copper regulators in yeast and HeLa cells.
From: Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism
Yeast gene | Effect of gene deficiency on Cu levels | Fold change | Human orthologues | Effect of gene deficiency on Cu levels | Fold change |
|---|---|---|---|---|---|
yCtr1 | Decrease | 0.58 | hCTR1/SLC31A1 | Decrease | 0.426 |
Atx1 | Slight decrease | 0.914 | ATOX1 | Increase | 1.296 |
yCCS | Decrease | 0.758 | hCCS | No change | 1.023 |
CCC2 | Slight decrease | 0.906 | ATP7A | Increase | 1.556 |
