Table 1 High frequency conserved interactions predicted by Mfold.

From: Regulation of human telomerase splicing by RNA:RNA pairing

Section 1 ex5-in5-ex6-in6

Section 2 in6-ex7-in7

Section 3 in7-ex8-in8

Section 4 in8-ex9-in9-ex10

Pairing nucleotide

% Output structures

Pairing nucleotide

% Output structures

Pairing nucleotide

% Output structures

Pairing nucleotide

% Output structures

1332C

24

3839C

69

4498C

100

4768C

100

580C

40

3767C

69

4470C

100

5390C

55

526C

24

3626C

72

4376T

100

5304T

90

799C

7

3054C

97

3943T

28

5343C

21

53T

7

2712C

69

  

5380C

14

632C

3

      

447C

7

      

202C

7

      

105T

3

      

555C

7

      

90C

3

      

467T

3

      
  1. Mfold analysis suggested that the consensus 38 bp block of repeats in TERT intron 6 consistently interacts with particular residues of the TERT pre-mRNA. Compensatory mutations were designed for the nucleotides showing the highest frequency among the output structures. The exact borders of the sections shown above do not correspond to the borders of the regions synthesized, which were chosen so that convenient restriction sites could be used to introduce the modified pre-mRNA.