Figure 6: A scheme of the cross talk between Hippo signalling and FoxO1.

In cardiomyocytes, YAP and FoxO1 form a functional complex that mediates catalase and MnSOD expression. In response to I/R, activation of the Hippo signalling cascade induces YAP inactivation, which leads to antioxidant gene suppression, ROS accumulation and cell death.