Figure 3: Induction of miR-146a is an ubiquitous phenomenon across cell types and enterovirus genus. | Nature Communications

Figure 3: Induction of miR-146a is an ubiquitous phenomenon across cell types and enterovirus genus.

From: Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon

Figure 3

(a–c) EV71 infection induced miR-146a expression (n=3) (a), suppressed IRAK1 and TRAF6 expressions (b) and enhanced AP1 expression (n=3) (c) in Caco-2 cells. MI, mock infection. (d) AntagomiR-146a restored EV71-induced suppression of TRAF6 and IRAK1 in Caco-2 cells. Caco-2 cells were transfected with antagomiR-146a or antagomiR-N.C. before virus infection. (e–g) PV3 and CVB3 infections induced miR-146a expression (n=3) (e), suppressed IRAK1 and TRAF6 expressions (f) and enhanced AP1 expression (n=3) (g) in RD cells. *P-value <0.05, Student’s t-test, as compared with mock infection.

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