Figure 5: Mortality and suppression of IFN production are dramatically improved in mEV71-infected miR-146−/− mice. | Nature Communications

Figure 5: Mortality and suppression of IFN production are dramatically improved in mEV71-infected miR-146−/− mice.

From: Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon

Figure 5

(a) miR-146a−/− mice displayed significantly high survival rates. miR-146a−/− mice or wild-type mice were infected with mEV71 and monitored daily for determination of survival rate. * represents the comparison between the 1 × 108 PFU/miR-146a KO group and the 1 × 108 PFU/WT group; ** represents the comparison between the 2 × 108 PFU/miR-146a KO group and the 2 × 108 PFU/WT group. (b) Representative clinical signs of paralysis and histological examinations in mEV71-infected mice. Magnifications, × 400; scale bar represented 200 μm. (c) Virus propagations were restricted in miR-146a−/− mice. Viral loads in indicated tissues were measured by plaque assay (n=4). The expressions of miR-146a (n=3) (d), IRAK1 and TRAF6 (e), IFNβ (n=3) (f) and IRF1 and IFIT1 (n=3) (g) in mEV71-infected wild-type or miR-146a−/− mice (mouse tissue samples pooling, n=4). The Kaplan–Meier method was used to estimate overall survival and the Log-rank test was performed to test the difference between survival curves.

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