Figure 1: Protein-blocked DSBs accumulate in Tdp2-deficient background upon TOP2 poison treatment.
From: ATM specifically mediates repair of double-strand breaks with blocked DNA ends
(a) Scheme of the strategy used to generate breaks with specific structure. (b) SLOPE assay performed in Tdp2+/+ and Tdp2−/− confluency-arrested primary MEFs. Average±s.e.m. of signal from three independent experiments and statistical significance by two-way ANOVA test with Bonferroni post-test is shown (*P≤0.05; **P≤0.01; ***P≤0.001).
