Figure 3: Paternal MHC does not educate uNK cells.
From: MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling
(a) Density plots showing the proportion of IFN-γ producing uNK (gd9.5+10.5) in response to NK1.1 cross-linking among cells positive or negative for the indicated Ly49 (irrespective of expression of other Ly49). (b–d) Fold change in IFN-γ producing cells among uNK expressing the indicated Ly49 compared with cells that do not. Ly49C/I (b), Ly49A (c) and Ly49A after exclusion of Ly49C/I+ cells (d). (e) Density plots showing MIP-1α producing uNK cells (gd9.5+10.5) in response to NK1.1 cross-linking among cells positive or negative for the indicated Ly49 (irrespective of expression of other Ly49). (f–h) Fold-change in MIP-1α producing cells among uNK expressing the indicated Ly49 compared with cells that do not. Ly49C/I (f), Ly49A (g) and Ly49A after exclusion of Ly49C/I+ cells (h). Pooled data from two experiments, n=6–11 mice per group. P-values comparing uNK subset expressing a given Ly49 with those that do not within each mouse using paired Student’s t-tests. Means±s.e.m.
