Figure 3: Chromatin marks are increasingly enriched on meQTL SNPs with larger effect sizes.
From: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
(a) We split cis-meQTL SNPs into five categories according to the meQTL association strength (P>10−7, 10−7>P>10−10, 10−10>P>10−15, 10−15>P>10−20 and P<10−20). A SNP is determined to be related with a regulatory region if the SNP or any LD-related SNP (r2≥0.8) resides in the ChIP-Seq peaks of the regulatory regions. Regulatory elements include CTCF-binding sites, DNaseI hypersensitive sites and histone marks from SAEC from ENCODE and hAEC from our laboratory. For each P-value category, we calculated the proportions of cis-meQTL SNPs related with regulatory regions. The figures show that the proportions of cis-meQTL SNPs related with regulatory regions increase with the significance of meQTL associations except for the repressive mark H3K27me3.
