Figure 4: DNA methylation regional associations for lung cancer GWAS SNPs in subjects of European ancestry.
From: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
(a,b,f,g) Symbols represent the association between established lung cancer GWAS genetic loci in four regions and methylation levels in nearby CpG probes. y coordinate, P-value for association; x coordinate, genomic location. For each SNP, the red solid circle or square represents the methylation probe with the strongest association, whereas other methylation probes are coloured on the basis of their correlation (measured as r2) to the most-associated probe. For the most-associated probes, the P-values in EAGLE discovery set (n=210) and TCGA lung replication data (n=65) are shown. SNP locations are marked by a blue triangle. (c–e and h–j) show the associations between genotypes and methylation levels of the most-associated CpG probes. The box plots show the distribution of the methylation levels in each genotype category with error bars representing the 25 and 75% quantiles.
