Table 1 Replication of EAGLE lung meQTLs in TCGA histologically normal tissue samples.
From: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
Tissue | N | All cis associations in EAGLE (34,304 associations, P <4.0 × 10−5) | Strong cis associations in EAGLE (12,083 associations, P <1.0 × 10−10) | All trans associations in EAGLE (585 associations, P <2.5 × 10−10) | |||
|---|---|---|---|---|---|---|---|
Consistent direction | FDR<0.05 | Consistent direction | FDR<0.05 | Consistent direction | FDR<0.05 | ||
Lung | 65 | 32,128 (93.7%) | 22,441 (65.4%) | 11,250 (99.3%) | 11,229 (92.9%) | 556 (95.2%) | 467 (79.8%) |
Breast | 87 | 30,391 (88.6%) | 18,762 (54.7%) | 11,640 (96.3%) | 9,987 (82.7%) | 561 (96.1%) | 488 (83.4%) |
Kidney | 142 | 30,975 (90.3%) | 23,984 (70.0%) | 11,634 (96.3%) | 10,783 (89.2%) | 558 (95.5%) | 506 (86.4%) |
