Figure 1: Schematic representation of TAM and three major isoforms of vertebrate ADMs, ADM-1, -2 and -5.
From: Horizontal gene transfer of a vertebrate vasodilatory hormone into ticks

Blue indicates the signal peptide (SP) sequences, and red indicates regions comprising mature ADM molecules, including TAM. Yellow indicates the processing sites used to liberate mature vertebrate ADM and PAMP. The putative TAM-processing sites are also shown in yellow. The two conserved Cys residues are indicated by dashed lines.