Figure 8: NR4A1 correlates with poor prognosis in breast cancer patients.
From: Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
(a) Kaplan–Meier curves showing that the relapse-free survival of individuals with NR4A1 expression is significantly lower than those without NR4A1 expression (P=0.008) by log-rank test. (b) Graph showing the correlation between NR4A1 expression levels and those of p-SMAD2 in TMAs from 175 samples from individuals with breast cancer. Not all spots were evaluable in all stainings. A Spearman’s test was used, and the correlation coefficient (Spearman’s ρ=0.354) and the two-tailed significance (P<0.001) are shown. (c) Representative images of NR4A1 and p-SMAD2 immunohistochemistry results are shown (scale bar, 50 μm). (d) Working model of NR4A1 in regulating TGF-β/SMAD signalling in breast cancer.
