Figure 5: Energy-minimized average model of POM-Aβ interactions. | Nature Communications

Figure 5: Energy-minimized average model of POM-Aβ interactions.

From: Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Figure 5

This complex is shown in molecular surface models (a) and a tube representation (b,c) with POM in green. A remarkable feature of the model is that the POM-binding site of Aβ is identified as a positive electricity cavity-like domain mainly encompassed by His13, Gln15, Lys16 of Aβ1–40. This is particularly visible in panel B. The complex is further stabilized by two hydrogen bonds, involving His13-POM and Arg16-POM. This is illustrated in c by arrows.

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