Figure 7: Metabolic pathways of (R)- and (S)-2HG.
From: Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
Red arrows represent non-enzymatic transformations observed in this study, black arrows represent identified metabolic pathways.1 L-maIDH, L-malate dehydrogenase; L-2-HGDH, L-2-hydroxyglutarate dehydrogenase; IDH2, isocitrate dehydrogenase 2; D-2HGDH, D-2-hydroxyglutarate dehydrogenase; HOT, hydroxyacid-oxoacid transhydrogenase enzyme; GBH, γ-hydroxybutyrate; SSA reductase, succinic semialdehyde reductase enzyme; SSADH, succinic semialdehyde dehydrogenase; GABA, γ-aminobutyric acid.
