Table 1 Chemical structures of modified siRNAs.

From: 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

	Sense (5′–3′)	Antisense (3′–5′)
UM	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCUAGAUGUAC
PS2-1	UGACAUGCCGAUCUACAU_S2G_S2TT	TTACUGUACGGCUAGAUGUAC
PS2-2	UGA_S2CAUGCCGAU_S2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
PS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_S2G_S2CUAGAUGUAC
PS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_S2AGAU_S2GUAC
MePS2-1	UGACAUGCCGAUCUACAU_MeS2G_MeS2TT	TTACUGUACGGCUAGAUGUAC
MePS2-2	UGA_MeS2CAUGCCGAU_MeS2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
MePS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeS2G_MeS2CUAGAUGUAC
MePS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeS2AGAU_MeS2GUAC
MePS-1	UGACAUGCCGAUCUACAU_MeSG_MeSTT	TTACUGUACGGCUAGAUGUAC
MePS2	UGA_MeSCAUGCCGAU_MeSCUACAUGTT	TTACUGUACGGCUAGAUGUAC
MePS-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeSG_MeSCUAGAUGUAC
MePS-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeSAGAU_MeSGUAC
Me-1	UGACAUGCCGAUCUACAU_Me G_MeTT	TTACUGUACGGCUAGAUGUAC
Me2	UGA_MeCAUGCCGAU_MeCUACAUGTT	TTACUGUACGGCUAGAUGUAC
Me-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_MeG_MeCUAGAUGUAC
Me-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_MeAGAU_MeGUAC
FPS2-1	UGACAUGCCGAUCUACAU_FS2G_FS2TT	TTACUGUACGGCUAGAUGUAC
FPS2-2	UGA_FS2CAUGCCGAU_FS2CUACAUGTT	TTACUGUACGGCUAGAUGUAC
FPS2-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FS2G_FS2CUAGAUGUAC
FPS2-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FS2AGAU_FS2GUAC
FPS-1	UGACAUGCCGAUCUACAU_FSG_FSTT	TTACUGUACGGCUAGAUGUAC
FPS2	UGA_FSCAUGCCGAU_FSCUACAUGTT	TTACUGUACGGCUAGAUGUAC
FPS-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FSG_FSCUAGAUGUAC
FPS-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FSAGAU_FSGUAC
F-1	UGACAUGCCGAUCUACAU_FG_FTT	TTACUGUACGGCUAGAUGUAC
F-2	UGA_FCAUGCCGAU_FCUACAUGTT	TTACUGUACGGCUAGAUGUAC
F-3	UGACAUGCCGAUCUACAUGTT	TTACUGUACG_FG_FCUAGAUGUAC
F-4	UGACAUGCCGAUCUACAUGTT	TTACUGUACGGCU_FAGAU_FGUAC

Chemical structures of modified siRNAs used for the initial screen. Locations of modification are indicated for each sequence.

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