Table 2 Thermostability of chemically modified siRNAs.

From: 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

siRNA sequence

Average Tm (°C)

s.d. (°C)

Δ Tm (°C)

UM

76.51

0.64

N/A

Me-1

76.68

0.50

0.17

PS-1

75.91

0.65

−0.60

MePS-1

76.37

0.08

−0.14

PS2-1

75.82

0.50

−0.69

MePS2-1

75.27

0.07

−1.24

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