Figure 5: MTSS1 exerts protumorigenic activity.
From: MTSS1 is a metastasis driver in a subset of human melanomas
(a) Left, immunoblotting for MTSS1 in human UACC-257 melanoma cells after RNA interference with MTSS1 expression through the indicated siRNA. Right, short-term soft agar colony formation to assay anchorage-independent growth via AlamarBlue staining. Bars represent mean optical density±s.d. of three replicates. Data were compared using the two-tailed Student’s t-test, ****P≤0.0001. (b) Kaplan–Meier tumour-free survival analysis for xenograft assays in athymic nude mice subcutaneously injected with empty-vector- or ectopic MTSS1-expressing HMEL cells in Matrigel. Data were compared using the Log-rank test.
