Figure 5: Improved animal survival and BM function do not alter GI radiation responses after 12 Gy TBI. | Nature Communications

Figure 5: Improved animal survival and BM function do not alter GI radiation responses after 12 Gy TBI.

From: Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

Figure 5

(a–d) WT or PUMA KO BMT recipients were analysed at indicated times for animal survival, crypt survival and apoptosis. (a) The Kaplan–Meier survival curve of BMT recipients. (b) Quantification of total crypts per cross-section of BMT mice. n=2 mice per group. (c) Representative images of TUNEL IF in BMT mice ( × 400 magnification). Scale bar, 25 μm. (d) Quantification of TUNEL in intestinal crypts of mice in c. n=3 mice per group. (e–h) WT or PUMA KO mice were exposed to 12 Gy TBI and analysed as in a–d. a,e were analysed by log-rank test. Values in b and f and d and h represent means+s.e.m., and means+s.d., respectively. **P<0.01, ***P<0.001 (Student’s t-test, two-tailed).

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