Figure 2: Phenotype summary.
From: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen
(a) lacZ reporter expression in skin. NA, not applicable because not determined. Left hand panel shows data for all mutants. Right hand panel shows data for those mutants with a skin phenotype. (b) Venn diagram showing overlap between the 50 genes identified with skin phenotypes in the screen, genes in the screen that are associated with any human disease or human skin/hair abnormalities, and genes associated with both mouse and human skin/hair abnormalities. (c) Heatmap showing all 50 phenotypic hits in the tail epidermal wholemount screen (top row), LacZ expression data from the MGP (bottom two rows) and the results of three macroscopic skin-related tests available through the MGP (middle rows). (d) Representative tail epidermal wholemount images of phenotypic hits from eight categories annotated using MP terms. Images are 3D maximum projections, except for Pex3−/−, which shows a single stack. (e) Association of each hit with the eight phenotypic categories annotated using MP terms. (f) Outlines of individual mutant HF and SG (red) compared with WT. WT and mutants are matched for genetic background. Scale bars, 100 μm.
