Figure 6: Mysm1−/− phenotype.
From: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen
(a) Adult Mysm1−/− homozygous mutant mice with short kinked white tails and white belly patches (arrows). (b) Stacked bars show incidence of abnormal tail morphology and epidermal wholemounts. See also the legend of Fig. 4d. (c,d) Epidermal wholemount images show disrupted HF pattern in Mysm1−/− mice when compared with WT. In d wholemounts were stained with the scale-specific marker ab1653 (ref. 16). (e) Haematoxylin and eosin (H&E)-stained sections showing parakeratotic interscale in WT and mutant tail epidermis. (f) STRING network image shows known (experimental) and predicted interaction partners of Mysm1. Scale bars, 100 μm (c–e).
