Figure 5: NMR studies on the foldamer 1.

(a) ¹H NMR spectra as a function of the concentration of 1 (298 K, 95% H₂O/5% D₂O, 30 mM CdSO₄, 100 mM HEPES pH 7.5 and 600 mM NaOAc). (b) Comparison of the same sample recorded in H₂O and D₂O shows the disappeared exchangeable protons E and F in D₂O highlighted by the dash lines. The H₂O sample was 8.2 mM compound in 30 mM cadmium sulphate, 100 mM HEPES pH 7.5, 600 mM sodium acetate and the D₂O sample was obtained by lyophilizing the H₂O sample overnight and then adding D₂O. (c) ¹⁹F NMR spectra as a function of concentration of 1 at 95% H₂O/5% D₂O, 100 mM HEPES pH 7.5, 1 M NaOAc and 50 mM CdSO₄. Assignments for protons A–F are given in Supplementary Figs 1 and 2. Peaks labelled with a * are impurities in the buffer.