Figure 1: Antibody F045–092 binds the influenza HA receptor-binding site. | Nature Communications

Figure 1: Antibody F045–092 binds the influenza HA receptor-binding site.

From: Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

Figure 1

Crystal structures of F045–092 Fab in complex with (a) Vic1975/H3 HA and (b) Vic2011/H3 HA. One Fab-HA protomer is coloured with HA1 in light blue, HA2 in green, the Fab heavy chain in purple and the Fab light chain in pink. Glycans are shown as spheres with carbon in yellow, oxygen in red and nitrogen in blue. (c) F045–092 binds HA using only its heavy chain and inserts its HCDR3 into the HA receptor-binding site. The HCDR3 contains a disulphide bridge, which is shown in yellow sticks.

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