Figure 2: Receptor-binding site recognition by F045–092 to Vic1975/H3 in comparison to the α2,6 sialoglycan receptor. | Nature Communications

Figure 2: Receptor-binding site recognition by F045–092 to Vic1975/H3 in comparison to the α2,6 sialoglycan receptor.

From: Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

Figure 2

(a) F045–092 inserts its HCDR3 into the HA receptor-binding site. The carboxylate side chain of F045–092 Asp100e overlaps with the (b) carboxylate moiety of the sialic acid of the α2,6 sialoglycan receptor (PDB 2YP4) and uses identical hydrogen-bonding interactions, which are shown as black dashed lines. An additional hydrogen bond between the main chains of F045–092 and HA is circled in red dashed lines. The Leu100d side chain of F045–092 overlaps with the acetamide moiety of sialic acid.

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