Figure 3: Sequence conservation of the F045–092 epitope across human H3 viruses. | Nature Communications

Figure 3: Sequence conservation of the F045–092 epitope across human H3 viruses.

From: Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus

Figure 3

(a) The F045–092 contact residues on HA are depicted as sticks. The per cent conservation for the most common residue found in the H3 subtype is labelled, which is not always identical to the residue at that position in the Vic1975/H3 sequence. (b) Interaction of F045–092 with Vic1975/H3 illustrating the sequence conservation of neutralizing epitope on the HA surface. For identification of the HA residues and positions that are colour coded on the surface, see (a). The F045–092 contact residues are labelled, coloured by HCDR, and shown as sticks. (c) Per cent identity of the most common residue among human H3 isolates plotted against the linear sequence of HA. Residues contacted by F045–092 or CR9114 are indicated by red or green diamonds, respectively. Although F045–092 contacts more hypervariable residues than CR9114 (but in different regions- head versus stem), it can still broadly neutralize the H3 subtype.

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