Figure 8: Model of assembly of Lar metallocenter.
From: Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system
(a) Assembly of urease metallocenter; one triangle represents one urease trimer of UreABC. UreD, UreE, UreF and UreG are the urease accessory proteins. (b) Proposed model for the assembly of Lar metallocenter. LarA is the Lar, while LarB, LarC and LarE are the Lar accessory proteins. (c) Assembly of [FeFe]-hydrogenase metallocenter. HydA is the [FeFe]-hydrogenase. HydE, HydF and HydG are the [FeFe]-hydrogenase accessory proteins. For clarity, the Fe–S clusters of [FeFe]-hydrogenase have been omitted. The purple balls represent Ni or a Ni-containing centre in (a,b). The dark red balls represent the H-cluster in (c). ATP, adenosine triphosphate; AMP, adenosine monophosphate; GTP, guanosine triphosphate; GDP, guanosine diphosphate; PPi, pyrophosphate, Pi, phosphate; SAM, S-adenosyl methionine.
