Figure 5: VM DA neurons load and display antigen.
From: MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
(a) VM DA neurons immunolabeled for TH and SIINFEKL-MHC-I. (b) The fraction of TH+ neurons that were labelled for SIINFEKL-MHC-I following vehicle, IFN-γ, OVA, IFN-γ+SIINFEKL and IFN-γ+OVA. Data are presented as the mean±s.e.m. (***P<0.001, one-way analysis of variance with Tukey post hoc test). Each experiment was repeated at least in triplicate and within each experiment, each condition was also performed at least three times. For each condition, neurons on n=24 fields at × 20 were quantified. Scale bar, 30 μm. IFN, interferon gamma; SIIN, SIINFEKL; Veh, vehicle.
