Table 1 MHC-I peptides associated with NM and identified by mass spectrometry analysis of samples isolated from human SN.
From: MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
Sample type | # | Peptide | Number of MHC-I sequences containing the peptide | HLA gene | Alleles encoding the peptide | Accession number (European Nucleotide Archive) |
|---|---|---|---|---|---|---|
NM-organelles 1 | 1 | YWDLQTRNVKAHSQTDRA | 2 | HLA-A | HLA-A*43:01 | X61703 |
(one subject) | HLA-A*29:20 | FJ222559 | ||||
2 | RNTQIFKTNTQTHRENLRIALRY | 1 | HLA-B | HLA-B*51:52 | AM906166 | |
3 | FLPTGGKGGSCSQAAS | 5 | HLA-C | HLA-C*03:04:01:01 | CR759828 | |
HLA-C*05:01:01:02 | BX248310 | |||||
HLA-C*06:02:01:01 | CR388229 | |||||
HLA-C*16:01:01 | BX927178 | |||||
ND | BC008457 | |||||
4 | QRMEPRAPWIEQERPAYW | 1 | HLA-A | HLA-A*31:22 | EU580147 | |
5 | VYSRHPAENGKSNFLNCYVSGFHPSDIE | 5 | B2M (Beta-2-microglobulin) | Not HLA gene | - | |
6 | PDGRLLRGYQQDAYDG | 105 | HLA-A/HLA-B | This peptide can be encoded by the allele HLA-B*74:11 (accession number: DQ888175) and by 104 alleles belonging to HLA-A*74 and HLA-A*32 allele families | ||
NM-organelles 2 | 1 | GHVRGVAPQIPGERE (a) | 9 | HLA-A | HLA-A*02:20:02 | AJ276069 |
(one subject) | HLA-A*02:08 | X94571 | ||||
ND | AJ429615 | |||||
ND | AY918166 | |||||
HLA-A*02:17:01 | X89707 | |||||
HLA-A*02:01:01:01/HLA-H*01:01:01:01/HLA-K*01:02 | CR388220 | |||||
HLA-A*02:250N | FN806794 | |||||
HLA-A*2new | AM905047 | |||||
HLA-A*68:13 | AM072964 | |||||
2 | HQAQVGGGPCGGAVESLPGGHVRG (b) | 9 | HLA-A | The same as above | ||
3 | FLPTGGKGGSCSQAAS | 5 | HLA-C | HLA-C*03:04:01:01 | CR759828 | |
HLA-C*05:01:01:02 | BX248310 | |||||
HLA-C*06:02:01:01 | CR388229 | |||||
HLA-C*16:01:01 | BX927178 | |||||
ND | BC008457 | |||||
NM isolated from SN tissues | 1 | RKLEAAGVAEQLRAYLEGECV | 1 | HLA-B | HLA-B*40:67 | AB257503 |
(five subjects) | 2 | DVGSDGRFLR | >1000 | HLA-A | This peptide can be encoded by >1000 different alleles of HLA-A gene | |
3 | NTQTDRESLRNLRCYYNQS | 1 | HLA-B | HLA-B*08:34 | AM778129 | |
4 | SLPGGRVRGVAPQIPGE | 1 | HLA-B | HLA-B*27:12 | Y14582 | |
5 | KWEAARVAEQLRAYLEGLCVEWLRRH | 27 | HLA-B | This peptide can be encoded by 27 alleles belonging to HLA-B*15, B*35, B*51, B*52, B*57, B*58 alleles families | ||
6 | DRETRDLTGNGKD | 56 | MICA | MICA*001 | ||
7 | LSSWTAADTAAQITQRKLEAA | 4 | HLA-B/HLA-C | HLA-B*40:77 | EF521874 | |
HLA-B*48new | DQ238865 | |||||
HLA-C*07:168 | HQ589100 | |||||
HLA-C*07:81 | FJ618920 | |||||
8 | ILRWEPSSQPTIPIVGIIAGLVL | 1 | HLA-A | HLA-A*02:134 | AM746482 | |
NM isolated from NM organelles | 1 | GHVRGVAPQIPGERE (a) | 9 | HLA-A | HLA-A*02:20:02 | AJ276069 |
(one subject) | HLA-A*02:08 | X94571 | ||||
ND | AJ429615 | |||||
ND | AY918166 | |||||
HLA-A*02:17:01 | X89707 | |||||
HLA-A*02:01:01:01/HLA-H*01:01:01:01/HLA-K*01:02 | CR388220 | |||||
HLA-A*02:250N | FN806794 | |||||
HLA-A*2new | AM905047 | |||||
HLA-A*68:13 | AM072964 | |||||
2 | HQAQVGGGPCGGAVESLPGGHVRG (b) | 9 | HLA-A | The same as above | ||
3 | FLPTGGKGGSCSQAAS (c) | 5 | HLA-C | HLA-C*03:04:01:01 | CR759828 | |
HLA-C*05:01:01:02 | BX248310 | |||||
HLA-C*06:02:01:01 | CR388229 | |||||
HLA-C*16:01:01 | BX927178 | |||||
ND | BC008457 | |||||
4 | FLPTGGKGGSCSQAASSNSAQGSD (d) | 5 | HLA-C | The same as above |
