Figure 6: H3 HCs increase synaptogenesis with blue cones in the absence of ultraviolet cones. | Nature Communications

Figure 6: H3 HCs increase synaptogenesis with blue cones in the absence of ultraviolet cones.

From: Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells

Figure 6

(a–d) Maximum intensity projections of confocal image stacks of whole mount eyes in the background of Tg(sws1:GFP; sws2:mCherry). Ultraviolet and blue cone distributions are shown for wild-type animals (a,b; control) and in the lor mutant (lor). Scale bars: 50 μm. (e–h) Example of an H3 HC visualized in lor, and its connectivity map. Inset in (e) shows a higher magnification view of enlarged dendritic tips within ultraviolet cones. Arrowheads in the orthogonal view of the cell (g,h) indicate dendritic tips invaginating blue cones. Scale bars, 5 μm. Note that in Fig. 7, some ultraviolet cones in lor receive more than one dendritic invagination from the same HC. We counted these tips as a separate ‘synapse’. (i–l) Summary of mean measurements in control (ctr) and lor. See Methods for details of analysis. Each open circle represents one H3 HC. Error bars are s.e.m. P-values from Wilcoxon–Mann–Whitney rank sum test.

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