Figure 1: Targeted RNAi screen to identify WWP-1 substrates involved in lifespan regulation. | Nature Communications

Figure 1: Targeted RNAi screen to identify WWP-1 substrates involved in lifespan regulation.

From: A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans

Figure 1

Percent change in mean lifespan in N2 worms (blue) or eat-2(ad1116) worms (red) treated with RNAi to the indicated genes only during adulthood compared with empty vector. Mean percent change of 1–4 independent experiments is shown. *P<0.05, **P<0.0001 (compared with same strain worms grown on HT115 bacteria harbouring the RNAi plasmid vector; Mantel–Cox log-rank test). Lifespan values are given in Supplementary Table 1.

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