Figure 4: wwp-1 and klf-1 function together to regulate diet-restriction-induced longevity.

(a–c) Lifespan analysis of worms overexpressing KLF-1 in the intestine (KLF-1 o/e) or control worms fed bacteria expressing klf-1 (a), wwp-1 (b) or pha-4 (c) dsRNA from hatching (L1) or control vector. (d) Lifespan analysis of WWP-1-overexpressing worms (WWP-1 o/e) or control worms fed bacteria expressing klf-1 dsRNA from hatching (L1) or control vector.