Figure 3: Elimination of the DMS cholinergic interneurons accelerates extinction learning performance.
From: Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons
(a,b) Place discrimination performance of the rats injected bilaterally with IT solution (a) or PBS (b) into the dorsal striatum. The performance in the acquisition and extinction learning phases were tested. IT injection: n=7 for non-Tg, n=6 for Tg; PBS injection: n=8 for non-Tg/Tg. *P<0.05, relative to the non-Tg rats (Bonferroni method). (c,d) Learning performance of the rats that received bilateral IT injection into the DMS (c) or DLS (d). DMS injection: n=6 for non-Tg, n=8 for Tg; DLS injection: n=6 for non-Tg, n=5 for Tg. *P<0.05, relative to the non-Tg rats (Bonferroni method). Data are presented as mean ±s.e.m.
