Figure 1: Fitness assay of heterozygous and homozygous mutation lines reveals variation in dominance among environments. | Nature Communications

Figure 1: Fitness assay of heterozygous and homozygous mutation lines reveals variation in dominance among environments.

From: Loss-of-heterozygosity facilitates passage through Haldane’s sieve for Saccharomyces cerevisiae undergoing adaptation

Figure 1

A comparison among lines for both maximal growth rate (a,b) and biomass production (optical density at 24 h, c,d) indicates that lines with heterozygous mutations (open purple circles) outperform lines with homozygous mutations (closed blue circles) in YPD ((a) growth rate, (c) biomass production) but were not capable of growth in YPD+2 μM nystatin ((b) growth rate, (d) biomass production). Lines on the x axis are arranged by the gene that carries a mutation; the lines farther to the left carry mutations in genes that are most upstream from the production of ergosterol, the end product of the pathway. When multiple mutations are present within a gene, the lines are arranged from 5′ to 3′ sites within the gene. Error bars reflect the s.e.m.s for each line from experiments conducted on five separate days for YPD and two separate days for nystatin.

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