Figure 4: Bmp7 treatment alters stereociliary bundle morphology in the proximal region of the BP.
From: A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear
(a) SEM images of hair cells in the indicated regions of the BP following following 6 DIV in control or Bmp7-media. Bmp7 treatment leads to notably smaller bundles in the proximal region of the BP. (b) Quantification of the mean length of the longest stereocilia within bundles located on proximal (black bars) or distal (grey bars) hair cells. Bmp7 induces a significant increase in the mean length of the longest stereocilia of proximal hair cells. (c) Quantification of mean number of stereocilia per hair bundle in proximal (black bars) and distal (grey bars) hair cells under the specified conditions. Bmp7 treatment induces a significant decrease in the number of stereocilia per bundle in proximal hair cells. Bmp7-induced changes in hair cell stereocilia are indicated (white arrows). Data are presented as mean±s.e.m. *P value<0.05 based on Student’s t-test. For controls n=4 and for bmp7-treated n=4.
