Figure 4: Putative NRPS and PKS gene clusters for ustiloxin and ustilaginoidin biosynthetic pathways. | Nature Communications

Figure 4: Putative NRPS and PKS gene clusters for ustiloxin and ustilaginoidin biosynthetic pathways.

From: Specific adaptation of Ustilaginoidea virens in occupying host florets revealed by comparative and functional genomics

Figure 4

(a) The putative NRPS gene (central long red arrow) cluster for ustiloxin biosynthesis. UV_1490 containing three adenylation domains may be responsible for the biosynthesis of the core structure of ustiloxins. The NRPS gene is clustered around genes encoding dehydrogenase, oxidase, monooxygenase and transcription factor that may be involved in the modification of secondary metabolites. (b) Comparison between the putative PKS gene cluster for ustilaginoidin biosynthesis in U. virens (upper) and the aurofusarin biosynthesis gene cluster in F. graminearum (bottom). The UV_2086 (PKS), UV_2087, aurT and gip1 genes (green) in U. virens were identified by BLASTing against the aurofusarin biosynthesis genes while other genes (purple) were predicted via Pfam domain search. The aurF and aurL2 genes (grey) in the aurofusarin biosynthesis gene cluster in F. graminearum are absent in U. virens genome.

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