Figure 3: Hepatocyte Tlr4 stimulates obesity-related tissue and systemic inflammation in mice.
From: Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance
(a) qPCR analysis of genes in epididymal WAT of HFD-fed mice (n=4–6). (b) Mac2 staining of epididymal WAT sections prepared from mice on HFD and quantification of crown-like structures. Scale bars, 100 μm. (c) qPCR analysis of genes in the liver of HFD-fed mice (n=4–6). (d) Plasma Tnfa, IL-6, IL-1β and Mcp1 levels in mice fed HFD (n=12–16 for Tnfα and Mcp1; n=9–10 for IL-1β and IL-6). *P<0.05, compared between Tlr4fl/fl and Tlr4LKO mice (Student’s t-test). All data are presented as means±s.e.m.
