Figure 7: Macrophage Tlr4 deficiency results in elevated circulating inflammatory cytokines in obese mice. | Nature Communications

Figure 7: Macrophage Tlr4 deficiency results in elevated circulating inflammatory cytokines in obese mice.

From: Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

Figure 7

(a) qPCR analysis of genes in epididymal WAT (n=5–7). (b) Plasma Tnfa, IL-6, IL-1β and Mcp1 levels in mice fed HFD for 12 weeks (n=10–13 for Tnfα, IL-1β and Mcp1; n=6–7 for IL-6). (c) qPCR analysis of genes involved in M2 macrophage activation in epididymal WAT (n=5–7). (d) Plasma IL-10 level in mice on HFD (n=6–7). *P<0.05, compared between Tlr4fl/fl and Tlr4ΔmΦ mice (Student’s t-test). All data are presented as means±s.e.m.

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