Figure 7: Murine IRG1 is detected within epidermal cells in a mouse model of atopic dermatitis and localizes to the mitochondria. | Nature Communications

Figure 7: Murine IRG1 is detected within epidermal cells in a mouse model of atopic dermatitis and localizes to the mitochondria.

From: Epidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fuelled matrix metalloproteinase production

Figure 7

(a,b) Immunohistochemical staining for IRG1 within skin biopsies taken from PBS-sensitized (a) and OVA-sensitized (b) mice, respectively. (c) Immunofluorescent detection of mitochondria and IRG1 within epidermis of OVA-sensitized mouse. (d) Line fluorescence intensity measurements, for line shown in c, for Mitochondria- and IRG1-specific signals demonstrating IRG1 associates with mitochondria. Representative images from n=4 separate PBS- and OVA-sensitized mice. Scale bars, 50 μm in a, 5 μm in c.

Back to article page