Figure 1: R-Ras2 plays roles in primary tumorigenesis. | Nature Communications

Figure 1: R-Ras2 plays roles in primary tumorigenesis.

From: Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

Figure 1

(a) Example of a primary tumorigenesis experiment with indicated orthotopically transplanted MDA-MB-231-Luc cells. Scale of bioluminescence signals obtained in tumour-bearing animals is shown at the bottom. (b) Growth kinetics of tumours formed by indicated MDA-MB-231-Luc cells. ***P≤0.001 relative to values obtained by control cells at final experimental time point (number of independent transplants is indicated in the figure); t-test. (c) Example of a primary tumorigenesis experiment with indicated MDA-MB-231-Luc cells. (d) Growth kinetics of tumours formed by indicated MDA-MB-231-Luc cells. ***P≤0.001 relative to values obtained by control cells at the final experimental time point (number of independent transplants is indicated in the figure); t-test. (e) Example of tumours formed by indicated 4T1 cells. t, tumour; *, lymph node. (f) Growth kinetics of tumours formed by indicated 4T1 cells. **P≤0.01; ***P≤0.001 relative to values obtained by either control cells or indicated experimental pairs (in brackets) at final experimental time point (number of independent transplants is indicated in the figure); t-test. In panels b, d and f, experimental values are given as mean± s.e.m.

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