Figure 2: R-Ras2 is important for breast cancer cell metastasis. | Nature Communications

Figure 2: R-Ras2 is important for breast cancer cell metastasis.

From: Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

Figure 2

(a) Lung metastases formed by indicated intravenously injected 4T1 cells. **P≤0.01 relative to control cell line (n=6, 12, 5 and 6 for 4T1-Control, KDRras2.c1, KDRras2.c2 and KDRras2.c3 cells, respectively); t-test. (b) Example of metastatic nodules (white spots) formed in lungs on intravenous injection of indicated 4T1 cells. (c) Lung metastases formed by indicated intravenously injected 4T1 cells. ***P≤0.001 relative to control cells (n=4, 5 and 6 for 4T1-Control, KDRras2.c1 and KDRras2.c1+R-RAS2 cells, respectively); t-test. (d) Examples of lung metastatic nodules formed by indicated intravenously injected 4T1 cell lines. (e) Lung metastases formed by indicated intravenously injected 4T1 cells. ***P≤0.001 relative to control cells (n=5). In this experiment, we injected suboptimal (5 × 104) numbers of 4T1 cells to pick up differences in metastatic node formation. (f) Example of lung metastatic behaviour of indicated intravenously injected MDA-MB-231-Luc cells (n=6). In panels a, c and e, experimental values are given as mean±s.e.m.

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