Figure 7: T-cell repertoire studies of graft infiltrates. | Nature Communications

Figure 7: T-cell repertoire studies of graft infiltrates.

From: Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance

Figure 7

(a) T cells infiltrating iPSC grafts show repertoire restriction. CDR3 length distribution of TCR sequences obtained from a representative syngeneic-rejected iPSC graft (left panel), accepted iEC graft (central panel) and accepted AEC graft (right panel). (b) T cells infiltrating iPSC grafts show a statistically significant expansion of a few dominant T-cell clones compared with iEC- or AEC-infiltrating cells. Results are pooled from two experiments, n=3 mice per group. (c) The T-cell repertoires of iEC and AEC grafts are statistically indistinguishable but different from iPSC repertoires. BCs of relatedness averaged for comparisons within experimental groups. Data are representative of mean±s.e.m. of three animals per group from two independent experiments are reported here. Significance of differences between series of results was assessed using unpaired two-tailed Student’s t-test; ***P<0.001, ****P<0.0001.

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