Figure 4: Significant associations between ncRNAs and protein coding gene families.

(a) Stress-responsive ncRNAs are significantly associated with a diverse set of functionally related groups of genes. Coloured cells correspond to ncRNAs (columns) that are positively correlated (Pearson’s ρ>0.7; purple) or anti-correlated (Pearson’s ρ<−0.7; green) to the expression profiles of a significant number of protein-coding transcripts in a given GO Slim category (rows), at FDR<5%. Selected families are highlighted. Complete annotation for all differentially expressed ncRNAs in both WT and atf21Δ strains can be found in Supplementary Fig. 7. (b) Specific functional associations for SPNCRNA.1164 in the WT and atf21Δ strains, as calculated for a; coloured using −log₁₀P-value.