Figure 6: The NS1 AR(T/S) motif is recognized by WDR5.
From: Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1
(a) ITC binding curves of WDR5 and the unmodified NS1 peptide. (b) Overall structure of WDR5 in complex with the NS1 peptide (yellow), compared with the histone H3 peptide (green, PDB ID: 2H13). (c) Two AR(T/S) motifs are present in the NS1 C terminus. (d) Comparison of the Rme0 (top, PDB ID: 2H13) and Rme2s (down, PDB ID: 4A7J) peptides recognition by WDR5. (e) Dissociation constants (μM) of WDR5 to histone H3R2 peptides with different methylation states. (a,e) Kd values were calculated from single measurement and errors were estimated by fitting curve.
