Figure 10: Proteasome inhibition 1 h before but not 1 h after CaMKIINtide treatment offsets memory impairment. | Nature Communications

Figure 10: Proteasome inhibition 1 h before but not 1 h after CaMKIINtide treatment offsets memory impairment.

From: pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning

Figure 10

(a) MG132 injected 1 h before treatment with CaMKIINtide at 6 h post training offsets the effect of CaMKIINtide on LTM. Untreated paired (no injection, N=22), DMSO-injected (Vehicle, N=14), and MG132→CaMKIINtide-injected (N=15) groups of animals all showed significantly higher feeding responses to the CS compared with CaMKIINtide-injected (N=23) and naive (N=22) animals. (b) MG132 injected 1 h after CaMKIINtide treatment at 6 h post training does not offset the effect of CaMKIINtide on LTM. The untreated paired (no injection, N=22) and DMSO-injected (Vehicle, N=13) groups of animals showed significantly higher feeding responses to the CS compared with CaMKIINtide-injected (N=23), CaMKIINtide→MG132 injected and naive (N=23) animals. Asterisks indicate significantly higher feeding responses to the CS compared with CaMKIINtide and naive levels in (a) and CaMKIINtide, CaMKIINtide→MG132 and naive levels in (b) (ANOVAs, P<0.001; Tukey’s, P<0.05). These experiments were replicated twice. All data are presented as means±s.e.m.

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