Figure 2: LncRNAs can be distinguished by canonical promoter and enhancer chromatin signatures. | Nature Communications

Figure 2: LncRNAs can be distinguished by canonical promoter and enhancer chromatin signatures.

From: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

Figure 2

(a) H3k4me3 and H3K4me1 binding across a 1 Kb interval centred on the transcription start site of expressed protein-coding genes. Profiles are sorted based on the height of the H3K4me3 peak. Also provided is a plot of the H3K4me1/H3K4me3 log2(ratio) at each TSS (mean over interval). (b) H3k4me3 and H3K4me1 binding across a 1 Kb interval centred on the transcription start site of differentially expressed lncRNAs. Profiles are sorted on the height of the H3K4me3 peak. Also provided is a plot of the H3K4me1/H3K4me3 log2(ratio) at each TSS (mean). (c) Example of a lncRNA with a canonical promoter-like chromatin signature (can-lncRNA, left) and a lncRNA with an enhancer signature (eRNA, right). Figures were produced using the UCSC genome browser.

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