Figure 2: Structural effects of SOX11 mutations. | Nature Communications

Figure 2: Structural effects of SOX11 mutations.

From: De novo SOX11 mutations cause Coffin–Siris syndrome

Figure 2

(a) Crystal structure of the mouse Sox4 HMG domain bound to DNA. Helices and loops are shown as green ribbons and threads, respectively. DNA is shown as grey sticks. Amino-acid residues at mutation sites are shown coloured red in the space-filling model. In the middle and right images, some of the amino-acid residues involved in the hydrophobic core surrounding mutation points are shown coloured green in the space-filling model. Amino-acid numbering is indicated for mouse Sox4 with that for human SOX11 in parentheses. Hydrogen bonds are shown as black dotted lines. Molecular structures were drawn using PyMOL ( http://www.pymol.org). (b) Free energy changes on the indicated mutations calculated by FoldX software.

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