Table 1 Identification of proteins with changed expression levels in iPSC-derived enriched neurons carrying GBA1 mutations.

From: iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

Protein

Gene symbol

Description

N. peptides

Fold change

Q7Z6G3

NECAB2

N-terminal EF-hand calcium-binding protein 2

4

1.9

Q15173-2

PPP2R5B

Serine/threonine-protein phosphatase 2 A 56 kDa regulatory subunit beta isoform

1

1.8

Q8NF91-4

SYNE1

Isoform 4 of Nesprin-1

1

1.7

Q8ND56-2

LSM14A

Isoform 2 of Protein LSM14 homolog A

5

1.7

Q9Y2Y0-2

ARL2BP

Isoform 2 of ADP-ribosylation factor-like protein 2-binding protein

2

1.4

P62979

RPS27A

Ubiquitin-40S ribosomal protein S27a

45

1.3

Q9BR76

CORO1B

Coronin-1B

5

1.3

Q8NC44

FAM134A

Protein FAM134A

1

−2.1

Q9HBL7

C9orf46

Transmembrane protein C9orf46

1

−1.5

Q9NUJ1

ABHD10

Abhydrolase domain-containing protein 10, mitochondrial

10

−1.2

  1. Summary of the identified proteins from quantitative mass spectrometry proteomics that were significantly (P<0.05, Student’s t-test) up- or downregulated in purified neurons from GBA-PD iPSCs compared with control neurons.
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