Figure 3: Retinal progenitors within hiPSC-derived RCs underwent spontaneous differentiation.
From: Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
Retinal progenitors differentiated following the typical central-to-peripheral pattern (a–c) and acquired early-born cell fates, beginning with generation of ganglion cells (BRN3-positive/EdU-negative, d–f), followed by photoreceptors (OTX2-positive, f), amacrine cells (AP2α-positive, g) and horizontal cells (AP2α/PROX1-positive, arrows in g). Scale bars, 50μm.
