Table 2 Significant copy-number variable regions.

From: The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

CNVR

Genes

Bands

Size (Kb)

No. of SNP

No. of Case

No. of Control

All

Europe

Africa

       

P -value

OR

P -value

OR

P -value

OR

del

ZNF280B

22q11.22

53.4

13

130

0

2.56E−57

Inf

1.94E−33

Inf

3.34E−04

Inf

del

* PARP8

5q11.1

47.7

8

70

8

2.76E−22

15.1

3.84E−13

12.0

2.69E−06

40.9

dup

* GABRB3

15q12

49.0

20

28

0

7.60E−13

Inf

1.50E−06

Inf

3.34E−04

Inf

dup

* GABRG3

15q12

135.3

13

27

1

3.72E−11

Inf

1.60E−05

19.5

3.34E−04

Inf

dup

* HERC2

15q13.1

84.4

2

24

0

4.12E−11

Inf

6.17E−06

Inf

3.34E−04

Inf

  1. CNVR=copy-number variable region; OR=odds ratio. The table shows CNVRs distinguishing cases from controls significant across both European-derived populations (P≤0.0001 by Fisher’s exact test) and African-derived populations (P≤0.001). For each CNVR, the table lists the type (del or dup), the closest gene impacted, the chromosomal band, the approximate size of the defect (Kb), the number of contributing SNPs, the numbers of affected cases and controls, as well as P-value and odds ratio (OR) from Fisher’s exact test for across all populations, and subsets of European-derived and African-derived populations.
  2. *Genes with an asterix (*) harbour CNVRs that disrupt their exons of directly, while those without the asterix are located in the genomic region around the intergenic CNVRs.
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