Figure 9: Elevated LSD1 levels protect mice from HFD-induced obesity and type-2 diabetes.
From: LSD1 promotes oxidative metabolism of white adipose tissue
(a) Body weight of Ctrl and Tg mice fed a high-fat diet (HFD). (b) Fat, lean and free body fluid (FBF) content of Ctrl and Tg mice fed a HFD. (c) H&E staining of ingWAT of Ctrl and Tg mice fed a HFD. Scale bar, 200 μm. (d) VO2, VCO2 and respiratory quotient (RQ) of Ctrl and Tg mice fed a HFD. (e) Serum glucose levels, (f) intraperitoneal glucose tolerance test (IPGTT) and (g) intraperitoneal insulin sensitive test (IPIST) of Ctrl and Tg mice fed a HFD. (a–g): n=10; s.d. represents+s.e.m. Statistical analysis was performed using two-tailed Student’s t-test. *P<0.05.
