Table 1 QCs and SCs have distinctly different properties
From: Three functionally distinct classes of C-fibre nociceptors in primates
QC | SC | Signif. | |
|---|---|---|---|
Conduction velocity (m s−1) | 0.89±.01 (118) | 0.86±0.01 (93) | NS |
Activity-dependent slowing of conduction (%)* | −21.5±0.8 (34) | −24.6±0.9 (33) | * |
Response to 49 °C, 3 s | |||
Latency to first AP (ms) | 202.1±6.5 (121) | 770.0±57.0 (95) | *** |
Peak discharge frequency (Hz) | 70.5±2.7 (121) | 6.99±0.6 (95) | *** |
Time of Peak discharge (ms) | 375.3±9.5 (121) | 1844.1±84.3 (95) | *** |
Total response (APs) | 26.3±0.6 (121) | 13.0±1.0 (95) | *** |
Response to heat staircase | |||
Heat Threshold (°C) | 40.8±0.2 (114) | 45.8±0.2 (91) | *** |
Total response (APs) | 32.8±1.1 (114) | 13.5±1.0 (91) | *** |
Mechanical response | |||
Threshold (bar) | 1.20±0.04 (121) | 2.03±0.08 (95) | *** |
Response to 8.9 bar (APs)* | 20.7±1.3 | 13.8 ±1.6 | ** |
Cold response (4 °C, 20 s) | |||
Incidence | 11/79 | 2/60 | # |
Burn response (48 °C, 120 s) | |||
Response during burn (APs) | 136±24 (12) | 351±46 (9) | *** |
Adaptation during burn (%)† | 29±4 (12) | 76±17 (9) | ** |
Change in heat threshold (°C) | −2.3±0.4 (12) | −4.1±0.8 (9) | * |
Change in response to staircase (%) | 212±41 (12) | 643±79 (9) | *** |
Chemical response | |||
Superficial cowhage‡ | |||
Incidence | 19/22 | 20/21 | NS |
Total response (APs per 5 min) | 97.1±13.7 (19) | 49.0±8.3 (20) | ** |
Superficial capsaicin | |||
Incidence | 15/15 | 1/15 | ### |
Total response (APs per 5 min) | 97.9±8.4 | 6.1±2.2 | *** |
Superficial histamine | |||
Incidence | 14/15 | 12/15 | NS |
Total response (APs per 5 min) | 41.8±4.9 | 23.1±4.5 | *** |
Intradermal histamine* | |||
Incidence | 11/27 | 22/32 | # |
Total response (APs per 5 min) | 15.4±3.6 | 28.9±4.0 | ** |
Intradermal β-alanine* | |||
Incidence | 27/27 | 12/32 | ### |
Total response (APs per 5 min) | 96.2±5.8 | 26.3±6.1 | *** |
